New Recommended paper @ F1000: Evaluated by NS with Ramachandra M Bhaskara !!

Entropic contributions and the influence of the hydrophobic environment in promiscuous protein-protein association.
Chang CE, McLaughlin WA, Baron R, Wang W, McCammon JA
Proc Natl Acad Sci U S A 2008 May 27 105(21):7456-61
Evaluated on: 4 Dec 2008

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Comment:
Chang et al. drive home the idea of alternative bound states of hydrophobic side-chains that are responsible for the binding and stabilization of promiscuous protein-protein association. Single proteins having multiple binding partners has been implicated as a causative factor in many diseases. This study can aid in the search for and design of drugs for promiscuous targets.
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Faculty Member:
Narayanaswamy Srinivasan with Ramachandra M Bhaskara

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Faculty Member: Structural Biology > Structural Genomics [ since 26 January 2007 ]