MBU Trip "Agumbe" 28th Feb -1st March, 2009 !!

Agumbe, the Cheerapunji of South India !!

"The capital of King Cobra"

PHOTOS
Snapfish Album

Agumbe is one of the most scenic places on the Western Ghats of the Southern India. Added to the lush green view all around, the attractions for the visitors is the spectacular sunset and vast opportunities it offers to the trekkers.

If you are looking for a peaceful break for a few days from the hectic city life, away from the crowded and commercialized attractions, then this is the place for you.

Agumbe is among the places that receive high rainfall and is rightly called the Cherrapunji of South India. Agumbe also served the screening of most of the episodes of one of the most popular television serial Malgudi Days based on R.K Narayan's novel.

DAY 0:
------
Departure: 27th February 2009, Friday @ 9:30 PM

DAY 1: 28th Feb 2009 ,Saturday
------

Reach Agumbe at ~ 7:00 AM --> Check in :MALLYA RESIDENCY --> Breakfast --> Trekking: ONAKE ABBE FALLS(3 Km)-->Lunch at trek site --> Reach JOGI GUNDI Water body & cave(2.5 km) --> SUNSET VIEW POINT(2 km) --> Back to LODGE. CAMP FIRE starts at 7:00 PM --> Dinner at the site of Camp fire --> Retire for the day by 10:00 PM

DAY 2: 1st Mar 2009 ,Sunday
-----

Start to SUNRISE POINT at 5:00 AM (18 km; 15 km by Bus) --> Back to LODGE & refresh --> Visit to HERITAGE HOUSE(1 km) and Breakfast there --> Reach Agumbe Rainforest Research Station (1.5 km) by 10:00 AM [Presentation by The Forest officer] --> Check Out from LODGE by 11:30 AM --> Reach SRINGERI --> lunch --> Start to Bangalore(Dinner on the way).

IISc Founder's Day 2009 !!

March 3rd is the birthday of Jamshetji Nusserwanji Tata (1839-1904), the visionary who laid the foundations for Science and Research in India: Indian Institute of Science , Bangalore. As a mark of respect to this noble individual, floral tributes are offered.

Founder's day 2008

PROGRAMME 2009

8.55 a.m. : Assembly in front of the Statue of Founder.
9.00 a.m. : Floral Tributes.

Aircraft Exhibition 28th Feb- 4th Mar, 2009 @ IISc !!

EXHIBITION ON Aircraft and how they work ?

Whatever we might like to call them - aeroplanes, aircraft, airplanes, or just planes - they have transported, and will carry on transporting, ever increasing numbers of people and tonnes of merchandise throughout the world. But the aeroplane is not just a means of transport, it is much more!

For over a hundred years, it has symbolised one of mankind's greatest adventures: aviation. The tales told by aviation pioneers are the stuff of dreams; thanks to their daring, we can actually fly, soaring through the clouds, faster, further and more safely.

The French exhibition "Aircraft: how do they work?" hosted by IISc with the support of Society For Shock Wave Research, Department of Aerospace Engineering is designed to give you an inside view of this spectacular adventure. By the time you leave this exhibition, we guarantee you will not only be immensely proud of the ingenuity demonstrated by yesterday's inventors, but much more able to imagine the next steps forward!

In other words: you will be able to admire the past, value the present, and trust in the future!

All are welcome to discover the fabulous world of aircrafts!

Inauguration !!
Saturday 28th of February 2009, at 9.30am at the
Choksi Hall, IISc Campus.

With the support of:

Society for Shock Wave Research,
Department of Aerospace Engineering

IISc Convocation Day!!

Degree Certificates offered to NS group members:
MS: Ramachandra M Bhaskara
PhD: V.S.Gowri

All Photos on web!! CHEMBIO 17-19th, Feb 2009 @ IISc & NCBS !!

Public Albums Online:
Day 1
Day 2
Day 3

Bloglinks:
Day 1, Day 2 , Day 3.


Prof Balaram B'day Celebrations



Photographs taken by Dinesh DC, NS Group, IISc, Blore

James Kitchen PhD, Visiting Student from Warwicker Group, Manchester, UK

From 15th March with NS Group

Dr Jim Warwicker
Personal details


Warwicker Group
People
Resources


Work @ their Group:

Structure, function and environment of proteins
Jim Warwicker, James Kitchen etc..

The physicochemical properties of proteins figure prominently in relation to invivo activity and in vitro characterization. Walter Kauzmann’s oil drop model for protein folding (1959, Adv Protein Chem 14:1-63) describes the most basic characteristic of native structures, the relatively non-polar interior, and has seeded numerous studies of computational folding over the last 3 decades. The rapid increase in the 3D structural database, with the influence of structural genomics initiatives, is providing information across a range of organism and subcellular environments. Our work seeks correlations between 3D-based calculated properties and biological/environmental characteristics, including the following examples: organism growth temperature; subcellular organelle and subcellular pH; propensity for phosphorylation; cysteine reactivity and redox control; DNA/RNA-binding surfaces and binding paths. Many of these areas have not been studied in detail previously, and in each case we find that calculations based on 3D structure can contribute to predictions of the biological properties, adding to what are generally sequence-derived predictive models. Phosphorylation is a good example of our methodology. Sequence-based approaches have dominated prediction of phosphorylation sites. Our study of phosphorylated sites in the PDB shows that many of these ‘real sites’ are separated from ‘control’ serine, threonine and tyrosine sites that are not phosphorylated (in the same PDB sets). The basis of this distinction is simply stabilization of the negative phosphate charge by surrounding groups. The set of phosphorylated proteins in the PDB may be biased compared with the wider phosphoproteome. However, mass spectrometry is revolutionizing the experimental field, indicating that phosphorylation may be more widespread than previously thought. Our structure and comparative model-based procedures could be a useful complement to sequence-based methods in phosphorylation site bioinformatics.
Research and calculations that investigate structural correlates of biological activity have become widespread since the advent of structural biology. However, the bioinformatics contribution to functional annotation of genes depends largely on sequence-based methods. In the context of our growing ability to structurally annotate genomes, 3D structural bioinformatics algorithms such as those outlined here assume a new importance in refining and complementing the primary structure techniques.


Contributors: Jim Warwicker, Richard Greaves, Pedro Chan, James Kitchen, David Walker, Binbin Liu, Salim Bougouffa, James Magee.

BMC Structural Biology Research Article

Indo-Brazilian Crystallography Meeting!! @ IISc on 23-25th Feb, 2009

Prof N. Srinivasan
25th Wed, Feb, 2009
Session IX: 09:30-10:00AM

Titled:
Influence of 3D structures of proteins in structure and function recognition at the genomic-scale.

Sandhya Sankaran PhD Work Presentation @ NCBS

Titled: Remote homology detection and Analysis of protein domain superfamilies


@ NCBS LH 1 4-5:30

Day 3: INTERNATIONAL SYMPOSIUM ON INTERFACE BETWEEN CHEMISTRY AND BIOLOGY

Venue: NCBS
Prof Balaram B'day Celebrations


Jayanth Udgaonkar

Balu P

Gathering

Ramaswamy

Balasubramanian D
Lunch and Poster session



Prof Balaram's B'day Celebration Photos
Prof Balaram's B'day Celebration Photos
Prof Balaram's B'day Celebration Photos
Web Picasa Album


Photographs taken by Dinesh D C, NS Group, IISc, Bangalore

4 Posters from NS Group @ CHEMBIO 2009

@NCBS 19th Feb

Nidhi Tyagi
Ramachandra Moorthy
Krishnadev
Anamika

Day 2: INTERNATIONAL SYMPOSIUM ON INTERFACE BETWEEN CHEMISTRY AND BIOLOGY

Venue: IISc, Faculty Hall

Jim Spudich & B Gopal
MRN Murthy
Shamala
Suman
Saraswathi
Sowdhamini

Chair: D Chatterji
Rajesh Ghokale

Hemalatha Balaram

Nagaraj R

Tapas Kundu

Day 1: INTERNATIONAL SYMPOSIUM ON INTERFACE BETWEEN CHEMISTRY AND BIOLOGY

Reception & Registration


The Hon'ble Speakers!!

Opening Remarks by D.N. Rao

Plenary Lecture by Victor Hruby



and many more.......

Program Schedule: INTERNATIONAL SYMPOSIUM ON INTERFACE BETWEEN CHEMISTRY AND BIOLOGY

Program Schedule: PDF


INTERNATIONAL SYMPOSIUM ON INTERFACE BETWEEN CHEMISTRY AND BIOLOGY

INDIAN INSTITUTE OF SCIENCE CAMPUS and in National Centre for Biological Sciences (TIFR) Bangalore

February 17- 19th 2009: This symposium brings together researchers from diverse areas like chemists, spectroscopists and molecular biologists who address fundamental problems in biology using chemical techniques. The symposium will cover areas like Peptide Conformation and Design, Membrane Biology, Structural Bioinformatics, Protein Engineering, Protein Folding and Drug Discovery, Chemical Ecology amongst other topics.

PROGRAM SCHEDULE


17th February, 2009

Venue: Indian Institute of Science, Faculty Hall

Plenary session

Chair: D.N. Rao
9:55 – 10:00 am Opening Remarks by D.N. Rao

10:00 – 10.45 am Plenary Lecture by Victor Hruby
Developing New Paradigms for Drug Design for Disease

10:45 – 11:15 am Tea break

Chair: Siddartha Sarma

11:15 to 11:45 am Satyajit Mayor
A hierarchy of scales: The tale of the morphogen, Hedgehog

11:45 am – 12:15 pm S. Sikdar
How does epileptiform activity affect Ca dynamics in neurons?

12:15 – 12:45 pm M.K. Mathew
Potassium Channel Opening: A Subtle Two-Step

12:45 pm to 2:00 pm LUNCH

Chair: Manju Bansal

2:00– 2:30 pm K.S. Krishnan
Synaptic Vesicle Recycling

2:30 – 3:00 pm K.N. Ganesh
Discovering unknown HIV Tat - NFkB interactions: Novel Applications of SELEX

3:00 – 3:30 pm Anna Spudich
Early European Records of Medicinal Plants of India: a valuable resource for drug discovery

3:30 to 4 pm Tea Break

Chair: C. Ramakrishnan

4:00 to 4:30 pm: J. Ramirez
Peptidergic and Aminergic Modulation of Respiratory Network Activity

4:30 to 5:00 pm: Raghavan Varadarajan
Influenza immunogen design

5:00 to 5:30 pm: Ramasarma
Vanadium Redox in Biological Oxidations

18th February 2009

Venue: Indian Institute of Science, Faculty Hall


Chair: B. Gopal

9:30 to 10 am: Jim Spudich
Single molecule and computational analyses reveal how the mysterious myosin VI molecular motor works

10 to 10:30 am: M.R.N. Murthy
New Insights into the structure and function of serinehydroxymethyl transferase

10.30to 11 am: Tea break

Chair: R. Sowdhamini

11 to 11:30 am : N. Shamala
Crystallographic Studies of Designed Peptides

11:30 am to 12 noon: Suman Thakur
Negative Ion Mass Spectrometry of Intact Disulfides and Bioactive Peptides

Chair: Nagasuma Chandra

12 to 12:30 pm: Saraswathi Vishweshwara
Long distance communication in proteins: Network dynamics of tRNA Synthetases

12:30 to 1 pm: R. Sowdhamini
Analysis of disulphide bond conservation within protein families

1 to 2 pm: LUNCH

Chair: Dipankar Chatterji

2 to 2:30 pm: Rajesh Ghokale
Role of Multifunctional Polyketide Synthases in Dictyostelium Development

2:30 to 3 pm: Hemalatha Balaram
Purine nucleotide synthesis in Plasmodium falciparum

3 to 3:30 pm: R. Nagaraj
Self-association of peptides on surfaces

3:30 to 4 pm: Tea Break

Chair: N. Srinivasan

4 to 4:30 pm: Tapas Kumar Kundu
Small molecules targeting epigenetic modifications, implications in gene expression from differentiation to disease

4:30 to 5 pm: Ranganathan
Exploration of pathways in silica solubilizatiion and biosilicification



19th February 2009

Venue: National Centre for Biological Sciences (TIFR)

Chair: P. Gautam

9:30 to 10 am: Jayant Udgaonkar
Hydrogen exchange-mass spectrometric characterization of the individual steps during the unfolding of a small protein

10 to 10:30 am: P. Babu
Lactase persistence mutations: An inspiration for DNA-DNA interaction?

10:30 to 11 am: Anil Kumar
Determination of three-dimensional structures of non-crystalline proteins in Solution by NMR

11 to 11:30 am: Tea Break

Chair: S. Brahmachari

11:30 to 12 noon: V.S. Chauhan
Peptide Design: From Models to Applications

12:00 to 12:30 pm: Mani Ramaswami
The control of mRNA translation: microRNAs, neurological disease and memory

12:30 to 1 pm: D. Balasubramanian
Optineurin and its Mutants: Molecules Associated With Some Forms of Glaucoma

1 to 3:30 pm: LUNCH and POSTER SESSION

3:30 pm: Closing Remarks by Prof. VijayRaghavan and others

5:30 pm: High Tea


http://www.ncbs.res.in/index.php?option=com_content&task=view&id=383&Itemid=9

The Story of INDIA !!

Check this Interesting Link:
INDIA
http://www.pbs.org/thestoryofindia/about/episode_summaries/

Synopsis

The world's largest democracy and a rising economic giant, India is now as well known across the globe for its mastery of computer technology as it is for its many-armed gods and its famous spiritual traditions. But India is also the world's most ancient surviving civilization, with unbroken continuity back into prehistory.
Like other great civilizations—Greece or Egypt, for example—over the millennia it has enjoyed not just one but several brilliant golden ages in art and culture. Its great thinkers and religious leaders have permanently changed the face of the globe. But while the glories of Rome, Egypt, and Greece, have all been the subject of TV portraits, as yet there has been no television story of India on our screens. This series sets out for the first time to do that: to show a world audience the wonders of India; the incredible richness and diversity of its peoples, cultures and landscapes; and the intense drama of its past, including some of the most momentous, exciting and moving events in world history.

eVoices newsletter of IISc, Feb. 2009 !!

PDF

The End of the Beginning by Arun R. (CSA)

Campus witnesses protest, Grievances to be addressed

Our Centenary... A perspective by Mukta (BIOCHEM)

Centenary Blues by Maneesh (MECHENG)

Reminiscences by Kumudhini (MGMT)

'Wellings-up' on listening to the Santoor by S. N. Balasubrahmanyam (Alumnus, ORGCHEM)

IISc: Past, present and future by Smrithy (MRDG)

The Doyenne of Biotechnology by Deepti (MRDG)

The Spirit of Volunteering by Abraham Kurian Plamthottam (MGMT)

Recollections till the Day Dawns by Brijesh N Bhatt (MCBL)

Centenary is on! by Suman S. Thakur (MBU)

Mechanism Design can help in achieving desired social goals: Prof. Eric Maskin by H. S. Sudhira (CES)

bhOndOO describes an Auto by Rupesh (CSA)

IISc students featured in Bangalore Mirror by Rupesh (CSA) and Maneesh (MECHENG)

My Pearl by Indumathi A. (MGMT)

Freedom by Divya Jain (Alumnus, CSA)

source:
http://www.ncsi.iisc.ernet.in/eVoices/?q=Feb2009

An excellent site to aid Protein Structural Analysis

Our Group Resources listed:

PALI - Phylogeny and ALIgnment of homologous protein structures.
SUPFAM - Clusters of potentially related homologous protein domain families.


More Resources

Visualization

CCP4 Molecular Graphics - Create beautiful publication quality images and movies.
Chimera - Interactive visualization and analysis of molecular structures and related data.
COOT - Main website for model-building/visualization program; COOT Manual
GRASP2 - Macromolecular structure and surface visualization written for the Windows.
LigPlot - Automatically plots protein-ligand interactions.
PYMOL - A molecular visualization system on an OPEN-SOURCE foundation. Wiki  Mailing-list
Raster3D - Program suite for photo-realistic molecular graphics.
SwissPDB Viewer - Swiss-PdbViewer (aka DeepView) is an application that provides a user friendly
interface allowing to analyze several proteins at the same time.  Tutorial
TopDraw - Sketchpad for drawing topology cartoons of proteins.

Structural and Sequence Alignment

AL2CO - Takes the multiple alignment and maps the positional conservation in the B-factor column of
the structure.
Baton - Structure based sequence alignment output file in the JOY format.
CE Combinatorial Extension Method - 3-D Protein Structure Comparison and Alignment.
CEMC -  Multiple protein structure alignment server.
ClustalW2 - A general purpose multiple sequence alignment program for DNA or proteins.
DALI - A server for comparing protein structures in 3D.
DALI Lite - Pairwise comparison of protein structures.
ESPript - Utility to generate a attractive PostScript output from aligned sequences.
FPS -  A method for scoring a query sequence against a family of sequences.
Homolmapper - Map several conserved properties onto your structures, not just plain sequence.
Indonesia -  Integrated program package for biological sequence analysis.
MAMMOTH - Multiple protein structure alignment server.
Mustang - Multiple structural alignment algorithm.
PALI - Phylogeny and ALIgnment of homologous protein structures.
Rapido - Alignment of protein structures in the presence of conformational changes. REF
SSM - Secondary Structure Matching: a tool for protein structure comparison
Stralign - Structure alignment program.
STRAP - Structure based alignment program.
Structural Alignment of SCOP Sequences - search the results of structural comparisons.
SUPFAM - Clusters of potentially related homologous protein domain families.
TCoffee - Evaluating multiple alignments of DNA, RNA, protein sequences and structures.
Theseus - Maximum likelihood superpositioning and analysis of macromolecular structures.
3D SS - Three dimensional structure superposition.

General Analysis

AMIGOS -  Reads an RNA PDB file and outputs a complete table of torsion angle calculations.
APBS - Software for evaluating the electrostatic properties of nanoscale biomolecular systems.
Atlas of Protein Side-Chain Interactions - depicts how amino acid side-chains pack.
CATH - Hierarchical classification of protein domain structures.
CAVENV - Designed to help visualise cavities in a protein structure.
CAVER - Automated calculation of pathways leading from buried cavities to outside solvent in static and
dynamic protein structures.
CaPTURE - Identify energetically significant cation-pi interactions within proteins.
CASTp - Computed atlas of surface topography of proteins.
ConSurf - Identification of Functional Regions in Proteins.
DDMP -- Differences Distance Matrix Program.
Dynamite - Makes predictions about the way a protein moves given only a PDB file.
Dynapocket - Prediction of likely configurations of the atoms of binding pocket.
DynDom - Determine domains, hinge axes and hinge bending residues in proteins.
dssp2pdb - Converts dssp output to pdb.
eF-site - Electrostatic surface of functional site.
elNemo - Compute the low frequency normal modes of a protein.
Entangle - Creates a listing of interactions that occur at the interface between the nucleic-acid/protein
complex. These interactions are then classified into hydrogen bonds, electrostatic, hydrophobic, and
Van der Waals.
ESCET - Analyse and compare three-dimensional protein structures.
extpdb - If you cut up pdb files, this is the utility for you.
FISH - Domain identification server.
GETAREA - Calculation of solvent accessible surface areas, atomic solvation energies and their
gradients for macromolecules.
GROMACS - Versatile package to perform molecular dynamics.
HBexplore - Geometrical analysis of hydrogen bonds in biological macromolecules.
InterPro - Database of protein families, domains, repeats and sites.
iMolTalk - Structural Bioinformatics Toolkit; an interactive, Internet-based service for computational
analyses in Structural Biology.
MOLEOline -  Web-based tool to find/analyze molecular channels, tunnels and pores.
MolProbity - An expert-system consultation about the accuracy of a macromolecular structure.
MOTIF - Sequence motif search from GenomeNet.
MSDMotif - Provides information about ligands, sequence and structure motifs.
NACCESS - Calculates the accessible area of a molecule from a PDB format file.
NCBI BLAST - Finds regions of similarity between biological sequences.
OCA - A browser-database for protein structure/function.
OnD-CRF - Order and Disorder in proteins prediction server.
Parvati -  Analysis/validation tool for high resolution protein structures.
PDBsum - At-a-glance overview of every macromolecular structure deposited in the PDB.
PDB Report Database -  Reports describing structural problems in PDB entries.
PDB Structure Quality - Determine if your structure is on-par with others in the PDB.
PDB2PQR Server - Enables a user to convert PDB files into PQR files.
Pfam - Large collection of protein families.
PIqsI - investigation and curation of quaternary structures.
PISA -  An interactive tool for the exploration of protein Interfaces, Surfaces and Assemblies.
Pre-BI - Prediction of biological interfaces.
PredictProtein - A service for sequence analysis, structure and function prediction.
Probe - Evaluate atomic packing, either within or between molecules. It generates “contact dots” where
atoms are in close contact.
ProDom - Protein domain families.
PRODRG-2 Server - Convert small molecules in PDB format to various topology formats.
ProFunc - Prediction of protein function from 3D structure; EBI services.
ProMate - Predicts the location of potential protein-protein binding sites.
PROPKA - Empirical Prediction and Interpretation of Protein pKa Values.
Protein Calculator - Protein properties calculator.
Protein Structure Prediction - Molecular modelling site.
Proteopedia - The collaborative, 3D encyclopedia of proteins and other molecules. Article
ProtSkin - Converts a protein sequence alignment to a property file used to map the
sequence conservation onto the structure of a protein.
PROTORP  - A tool to analyse the properties of interfaces of protein-protein associations.
PSAIA - Software tool  that integrates several algorithms for protein interactions and structure geometry
analysis of protein complexes into a single application.
RAPPER - An ab initio conformational search algorithm for restraint-based protein modelling.
ROBETTA - Full-chain protein structure prediction server.
SCOP - Structural classification of proteins.
SFCheck - Assessment of X-ray data and/or agreement between atomic model and X-ray data.
SPASM Server - Server will find similar motifs based in a database derived from the PDB.
SSBOND - predicts sites where disulphide bonds can be introduced.
STAN - Structure analysis server.
StrucTools - Common structural biology calculations with PDB coordinates.
SURFNET - Generates surfaces and void regions between surfaces.
TLSMD - Inference of TLS motion from single crystal structures.
TOPS - Compare a structure (PDB Format) to a database of structures.
Web-Tools - Web-Accessible Scientific Applications (scientific supercomputing at NIH).
WHAT IF - Homology modelling, drug docking, electrostatics, validation and visualisation.
3Dee - Database of Protein Domain Definitions.
3DNA - Analysis, rebuilding, and visualization of three-dimensional nucleic acid structures.


source: http://www.pxuniverse.com/Websites.html

Aero India 2009, Bangalore from 11 to 15 Feb !!

The Venue of Aero India Show 2009, Yelahanka, a suburb of Bangalore in Karnataka.

Aero India Show was popular since the first exhibition in 1996. Now, all waiting for the next Aero India Show 2009. This air show is held twice at Yelahanka Air Force Base in Bangalore. Aero India Show is considered to be one of the largest air show in South Asia, where thousands of visitors come.

Aero India 2009

The Aero India show in India is very popular especially among people associated with the aviation industry and aviation industry. The service providers and manufacturers can learn about technology and products from this show. 592 Exhibitors from 25 Countries will participate in the show.

Participating countries including the United States, Australia, Britain, Brazil, Czech Republic, India, Belguim, France, Italy, Germany, Ireland, Malaysia, Israel, Norway, Romania, Poland, Singapore, Russia, South Africa, Sweden, Spain, Ukraine, Holland and Switzerland. The Aero India show in India is very popular especially among people associated with the aviation industry and aviation industry. Some expected to break previous records are aimed at the upcoming Aero India Show 2009.



The Aero India 2009 Exhibition is organized by the Defense Ministry of India in association with the Federation of India Chambers of Commerce and Industry (FICCI). The fourth largest air show in the world the Aero India is one of the major exhibitions in India as it includes both air displays and exhibitions of various aircrafts of the Indian Air Force. The Aero India has been conducted 6 times in India and the last three editions showcased some of the most advanced technologies and aviation equipments.

Seminar in NCBS by Dr. Subhojyoti De from Cambridge

Subhajyoti De

MRC Laboratory of Molecular Biology
Hills Road, Cambridge CB2 2QH, United Kingdom
Ph: 0044-(0)1223-402479

• 2008 Elected Fellow of King's College, Cambridge

2005 – (2008) PhD in Biology (Biostatistics and Computational Genomics)
MRC Laboratory of Molecular Biology, Cambridge, UK
Investigated trends of population-level diversity and evolutionary
divergence in the human lineage and identified specific patterns of
evolutionary constraints on the human genome and transcriptome.

2003 Indian Institute of Science, Bangalore, India
• Worked as an intern with Dr. N.Srinivasan investigating the difference in interface properties between transient and permanent complexes.
• Received JNCASR Summer Research Fellowship.


Research Page
CV

New Recommended paper @ F1000: Evaluated by NS with Ramachandra M Bhaskara !!

Entropic contributions and the influence of the hydrophobic environment in promiscuous protein-protein association.
Chang CE, McLaughlin WA, Baron R, Wang W, McCammon JA
Proc Natl Acad Sci U S A 2008 May 27 105(21):7456-61
Evaluated on: 4 Dec 2008

Full text

Comment:
Chang et al. drive home the idea of alternative bound states of hydrophobic side-chains that are responsible for the binding and stabilization of promiscuous protein-protein association. Single proteins having multiple binding partners has been implicated as a causative factor in many diseases. This study can aid in the search for and design of drugs for promiscuous targets.
more

Faculty Member:
Narayanaswamy Srinivasan with Ramachandra M Bhaskara

View NS page @ F1000
Faculty Member: Structural Biology > Structural Genomics [ since 26 January 2007 ]

National Symposium on Cellular and Molecular Biophysics @ CCMB

Under the aegis of The Indian Biophysical Society
January 22-24, 2009
CCMB, Hyderabad, India - 500 007

Participants from NS Group:

Paper presented:
Analysis of Low Resolution Structures of Protein Assemblies: A Case Study with Clathrin
Rupali A. Gadkari

Poster presented:
Towards stabilizing domain folds in multi-domain proteins
Ramachandra M Bhaskara


Website