NATIONAL CENTRE FOR BIOLOGICAL SCIENCES
TATA INSTITUTE OF FUNDAMENTAL RESEARCH
GKVK, BELLARY ROAD, BANGALORE
Date : Thursday, September 24, 2009
Time : 11:30 a.m.
Speaker : Dr. Aswin Sai Narain Seshasayee,EMBL-European Bioinformatics Institute, UK
Title : Bacterial regulomics: from networks to histones
Venue : Ground Floor Lecture Hall (LH1)
Bacteria are the most dominant form of free-living life on earth. Many bacterial live in multiple habitats each offering its own set of nutrients and adversaries. As part of adaptation to a given habitat bacteria make use of numerous signal-transduction mechanisms largely leading to a change in the transcriptional status of the cell. This is best exemplified by the metabolic system whose regulation can be conceptualised in the form of at least two genome-scale networks - one describing the metabolic system itself and the other icluding its regulators. Aiming to present an overview of our wholly computational work into signal-dependent regulation in bacteria, I will present a computational, functional genomic study of the architecture of genome-scale networks describing regulation of metabolism by small-molecules.
Bacterial gene regulation goes beyond specific, signal-dependent control, and includes large-scale, global regulation by histone-like / nucleoid-associated proteins. I will briefly present initial work, on three such proteins in E. coli, that make use of genome-scale experimental approaches. This will lead on to thoughts on future directions.
Co-ordinator: Dr. Mukund Thattai (email@example.com)
ALL ARE WELCOME